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The press center of the Ministry of Foreign Affairs of Uzbekistan said that Islam Karimov sent the message of condolences to Italian President Sergio Mattarella.
Uzbek President conveyed compassion and empathy to the families and relatives of victims and those injured.
As earlier reported, the 6.2-magnitude quake hit at 03:36 (01:36 GMT) on Wednesday 100km north-east of Rome. Dozens of people are believed trapped in ruined Amatrice, Accumoli and Pescara del Tronto, in mountainous central Italy.
The death toll in the Italian earthquake stands at 241 as rescuers continue efforts to find survivors.