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Bunyodkor striker Oleksandr Pishur was dismissed on 10 minutes after he tackled defender of Pakhtakor.
The score was opened at the end of the first half. Igor Sergeev netted the goal in the first added minute to the first half.
Igor Sergeev recorded a brace on 46 minutes of the match, while Kahi Makharadze increased Pakhtakor lead five minutes later.
On 85 minutes, Bunyodkor scored a goal via efforts of the striker Vohid Shodiev.
Locomotiv and Pakhtakor are leading in the Uzbek league with 33 points after 13 matches.